Lactadherin mediates sickle cell adhesion to vascular endothelial cells in flowing blood.
نویسندگان
چکیده
Increased exposure of sickle red blood cells to phosphatidylserine promotes its adhesion to the endothelium. A monoclonal antibody to lactadherin, a phosphatidylserine binding protein, inhibits sickle cell adhesion to histamine-stimulated endothelial cells in flowing blood. Added lactadherin enhances the adhesion via the integrin alphaVbeta3. These results indicate that lactadherin can mediate phosphatidylserine-expressing sickle cell adhesion to the endothelium.
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عنوان ژورنال:
- Haematologica
دوره 92 9 شماره
صفحات -
تاریخ انتشار 2007